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Year 2016 - Volume 36, Number 4
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Employment of electrochemotherapy for cutaneous squamous cell carcinoma in cats, 36(4):297-302
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ABSTRACT.- Silveira L.M.G., Cunha F.M., Brunner C.H.M. & Xavier J.G. 2016. [Employment of electrochemotherapy for cutaneous squamous cell carcinoma in cats.] Utilização de eletroquimioterapia para carcinoma de células escamosas tegumentar em felino. Pesquisa Veterinária Brasileira 36(4):297-302. Setor de Cirurgia da Faculdade de Medicina Veterinária, Universidade Paulista, Av. Tenente Julio Prado Neves 965, São Paulo, SP 02370-000, Brazil. E-mail: lmgsilveira@gmail.com
Electrochemotherapy is characterized as a protocol which combines the use of antineoplastic agents and localized application of electric pulses (electroporation) to improve the intracellular concentration of these agents, increasing its cytotoxic action. Bleomycin, an antibiotic agent with antineoplastic properties, is a hydrophilic molecule, having a restricted transport through the cellular membrane. However, when it is administered intralesionally or intravenously and associated to electroporation, its cytotoxicity is maximized. There were utilized 21 cats affected by cutaneous squamous cell carcinoma. The electrochemotherapy protocol was standardized using intravenous bleomycin sulfate at a dose of 15U/m2 body surface area. Electroporation was performed using an electrode composed of needles and electric pulses with 1000 V voltage, in unipolar square wave and 100 microseconds duration, totalizing eight cycles. There was complete neoplastic remission in 21 cats (100%). There were no complications or side effects associated with the procedure. The protocol studied in this work showed to be feasible, effective and safe for antineoplastic therapy in feline cutaneous squamous cell carcinoma. |
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