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Year 2019 - Volume 39, Number 6
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Fatal hemothorax caused by pleural mesothelioma in a lion, 39(6):416-418
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ABSTRACT.- Rocha P.R.D., Duarte R.P., Laranjeira M.G., Melo T.A.L., Azevedo E.Z., Garcia S.D. & Machado G.F. 2019. Fatal hemothorax caused by pleural mesothelioma in a lion. [Hemotórax fatal causado por mesotelioma pleural em um leão.] Pesquisa Veterinária Brasileira 39(6):416-418. Faculdade de Medicina Veterinária, Universidade Estadual Paulista “Julio de Mesquita Filho”, Rua Clóvis Pestana 793, Dona Amélia, Araçatuba, SP 16050-680, Brazil. E-mail: giselem@fmva.unesp.br
Mesothelioma is considered a malignant neoplasm caused by the proliferation of mesothelial cells mostly from the pleura, peritoneum and pericardium. Here we described a case of fatal hemothorax caused by pleural mesothelioma in a lion by means of necropsy, histopathology and immunohistochemistry. Gross inspection of the thoracic cavity showed hemothorax with about 4 liters of blood. Microscopically, numerous, randomly distributed, soft, red-pink, irregular masses with up to 1cm in diameter were observed in both visceral and parietal pleurae. Microscopically, a papillary structure pattern was observed in the thoracic masses, composed mainly by one layer of cubic mesothelial cells, which presented eosinophilic cytoplasm, central nucleus and evident nucleolus, supported by a low cellular fibrovascularstroma. Neoplastic cells were positive for both cytokeratin and vimentin by immunohistochemistry. This seems to be the first report of fatal hemothorax caused by pleural mesothelioma in a lion. |
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