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Year 2019 - Volume 39, Number 5
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The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology, 39(5):364-370
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ABSTRACT.- Sasahara T.H.C & Machado M.R.F. 2019. The effect of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) on mice myocardial morphology. Pesquisa Veterinária Brasileira 39(5):364-370. Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Cidade Universitária, Avenida Prof. Orlando Marques de Paiva 87, São Paulo, SP 05508 270, Brazil. E-mail: tsasahara@gmail.com
Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle. |
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